How To Install hhsuite on Debian 12
Introduction
In this tutorial we learn how to install hhsuite on Debian 12.
What is hhsuite
hhsuite is:
HH-suite is an open-source software package for sensitive protein sequence searching based on the pairwise alignment of hidden Markov models (HMMs).
This package contains HHsearch and HHblits among other programs and utilities.
HHsearch takes as input a multiple sequence alignment (MSA) or profile HMM and searches a database of HMMs (e.g. PDB, Pfam, or InterPro) for homologous proteins. HHsearch is often used for protein structure prediction to detect homologous templates and to build highly accurate query-template pairwise alignments for homology modeling.
HHblits can build high-quality MSAs starting from single sequences or from MSAs. It transforms these into a query HMM and, using an iterative search strategy, adds significantly similar sequences from the previous search to the updated query HMM for the next search iteration. Compared to PSI-BLAST, HHblits is faster, up to twice as sensitive and produces more accurate alignments.
There are three methods to install hhsuite on Debian 12. We can use apt-get, apt and aptitude. In the following sections we will describe each method. You can choose one of them.
Install hhsuite Using apt-get
Update apt database with apt-get using the following command.
sudo apt-get update
After updating apt database, We can install hhsuite using apt-get by running the following command:
sudo apt-get -y install hhsuite
Install hhsuite Using apt
Update apt database with apt using the following command.
sudo apt update
After updating apt database, We can install hhsuite using apt by running the following command:
sudo apt -y install hhsuite
Install hhsuite Using aptitude
If you want to follow this method, you might need to install aptitude first since aptitude is usually not installed by default on Debian. Update apt database with aptitude using the following command.
sudo aptitude update
After updating apt database, We can install hhsuite using aptitude by running the following command:
sudo aptitude -y install hhsuite
How To Uninstall hhsuite on Debian 12
To uninstall only the hhsuite package we can use the following command:
sudo apt-get remove hhsuite
Uninstall hhsuite And Its Dependencies
To uninstall hhsuite and its dependencies that are no longer needed by Debian 12, we can use the command below:
sudo apt-get -y autoremove hhsuite
Remove hhsuite Configurations and Data
To remove hhsuite configuration and data from Debian 12 we can use the following command:
sudo apt-get -y purge hhsuite
Remove hhsuite configuration, data, and all of its dependencies
We can use the following command to remove hhsuite configurations, data and all of its dependencies, we can use the following command:
sudo apt-get -y autoremove --purge hhsuite
Dependencies
hhsuite have the following dependencies:
References
Summary
In this tutorial we learn how to install hhsuite package on Debian 12 using different package management tools: apt, apt-get and aptitude.